Table 2 Histological characteristics according to HPV status
Total (n = 93) | HPV DNA negative (n = 64) | HPV DNA positive (n = 29) | p value | |
|---|---|---|---|---|
Vulvar squamous cell carcinoma subtype | ||||
Keratinizing | 73 (78%) | 52 (80%) | 21 (72%) | 0.701 |
Basaloid | 5 (5%) | 2 (3%) | 3 (10%) | |
Nonkeratinizing | 13 (14%) | 9 (14%) | 4 (14%) | |
Hybrid (warty + basaloid) | 2 (2%) | 1 (3%) | 1 (4%) | |
Histological grade | ||||
Well differentiated | 21 (23%) | 13 (20%) | 8 (28%) | 0.514 |
Moderately differentiated | 50 (54%) | 37 (58%) | 13 (45%) | |
Poorly differentiated | 21 (23%) | 13 (20%) | 8 (28%) | |
Tumor depth of invasion (mm), median, (range) | 5 (0.4–35) | 4.6 (0.4–35) | 6 (0.7–20) | 0.156 |
Vulvar intraepithelial neoplasia of usual type | 20 (22%) | 13 (20%) | 7 (24%) | 0.786 |
Vulvar intraepithelial neoplasia of differentiated type | 9 (10%) | 9 (14%) | 0 (0%) | 0.03 |
Koilocytotic change | 30 (32%) | 15 (23%) | 15 (52%) | 0.006 |
Peritumoral lymphocytic infiltrate | ||||
Absent | 12 (13%) | 7 (11%) | 5 (17%) | 0.772 |
Light | 33 (35%) | 24 (38%) | 9 (31%) | |
Moderate | 43 (46%) | 29 (45%) | 14 (48%) | |
Heavy | 5 (5%) | 4 (6%) | 1 (3%) | |
Invasive front | ||||
Pushing | 23 (25%) | 14 (22%) | 9 (31%) | 0.439 |
Infiltrating | 69 (75%) | 49 (77%) | 20 (69%) | |
