Table 3 Immunohistochemical results in HPV DNA positive primary tumors by HPV type

From: CD274 (PD-L1), CDKN2A (p16), TP53, and EGFR immunohistochemical profile in primary, recurrent and metastatic vulvar cancer

 

No. of primary tumors

CDKN2A+

TP53+

EGFR+

CD274+

Low-risk HPV

 HPV6

2

0/2

1/2

0/2

0/2

 HPV53

1

0/1

1/1

0/1

0/1

High-risk and possible high-risk HPV

 HPV16

11

8/11

1/11

2/11

1/11

 HPV31

2

0/2

0/2

0/2

0/2

 HPV33

1

1/1

0/1

0/1

1/1

 HPV39

1

0/1

0/1

0/1

0/1

 HPV51

2

0/2

1/2

0/2

0/2

 HPV66

1

0/1

0/1

0/1

1/1

Not determined

 HPV70/HPV39

1

0/1

1/1

0/1

1/1

 HPVX

4

0/4

2/4

0/4

1/4

 Total

26

9/26

7/26

2/26

5/26