Fig. 5: Spitzoid melanoma with a class 3 BRAF mutation.
From: Spitz melanoma is a distinct subset of spitzoid melanoma
a Low power view of case 19 which harbors BRAFD594G mutation along with EZH2Y646S, BLMW803*, MAP2K2F57Y, and TERT promoter mutations. The neoplasm is predominantly dermal and is composed of coalescing nests and sheets of large epithelioid melanocytes with a focally dense infiltrate of lymphocytes. b Medium power shows a predominantly nested architecture with numerous admixed lymphocytes. c Nuclei are pleomorphic with prominent nucleoli and brisk mitotic activity (arrows).
