Fig. 2: Ovarian immature teratomas are characterized by extensive genomic loss of heterozygosity. | Modern Pathology

Fig. 2: Ovarian immature teratomas are characterized by extensive genomic loss of heterozygosity.

From: Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components

Fig. 2

Plots of ∆allele frequency (∆AF) were generated from the whole-exome sequencing data for each of the 52 tumor regions from ten patients with ovarian immature teratomas. Two distinct tumor clones were identified in four patients (b, g, h, and j) who all had bilateral ovarian teratomas. While all tumor regions harbored a 2N diploid or near-diploid genome, extensive genomic loss of heterozygosity was observed in each of the different tumor components analyzed. Each point represents one informative polymorphic locus. Points near the top of the y-axis represent single nucleotide polymorphisms that are homozygous in the tumor, whereas points near the bottom of the y-axis are heterozygous. y-axis, ∆AF. x-axis, chromosome. Dotted line, centromere. ∆AF is calculated as the absolute difference between theoretical heterozygosity (AF = 0.5).

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