Table 3 Local recurrence rates in prospective studies of low risk ductal carcinoma in situ treated with breast conserving surgery alone.
From: Diagnosis of ductal carcinoma in situ in an era of de-escalation of therapy
Study | Study type | Entry criteria | # | Local recurrence rate |
|---|---|---|---|---|
Harvard [27] | Single arm | • Low/intermediate nuclear grade • ≤2.5 cm • Margins ≥10 mm or negative re-excision | 158 | 15.6% (10 years) (1.6%/year) |
ECOG 5194 [28] | Single arm | • Low/intermediate nuclear grade • ≤2.5 cm • Margins ≥3 mm | 565 | 14.4% (12 years) (1.2%/year) |
RTOG 9804 [29] | Randomized clinical trial | • Low/intermediate nuclear grade • ≤2.5 cm • Margins ≥3 mm | 298 | 11.4% (12 years) (1.0%/year) |
