Fig. 10: The morphologic spectrum of partial hydatidiform moles. | Modern Pathology

Fig. 10: The morphologic spectrum of partial hydatidiform moles.

From: Refined diagnosis of hydatidiform moles with p57 immunohistochemistry and molecular genotyping: updated analysis of a prospective series of 2217 cases

Fig. 10

a–c Three different examples demonstrate the more typical spectrum of villous morphology, with classical enlarged fibrotic to hydropic and irregularly scalloped villi with variable trophoblastic hyperplasia and some trophoblastic inclusions (all were p57-positive [not shown]). d Another example with rounded hydropic villi having more trophoblastic hyperplasia suggests a complete hydatidiform mole but p57 was positive (not shown). e, f Bulbous smaller villi with trophoblastic hyperplasia on villous tips and myxoid stroma with canalicular vessels suggest an early complete hydatidiform mole but p57 expression is present in villous cytotrophoblast and stromal cells. Typical diffuse (g) and focal (h) p57 staining patterns in partial hydatidiform moles. Essentially all villous cytotrophoblast and stromal cells are positive in g but only some cells are positive in h (overall this was less than 50% in the stained section). All cases demonstrated diandric triploidy per genotyping.

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