Fig. 13: Genotyping result for the digynic triploidy example in Fig. 12a. | Modern Pathology

Fig. 13: Genotyping result for the digynic triploidy example in Fig. 12a.

From: Refined diagnosis of hydatidiform moles with p57 immunohistochemistry and molecular genotyping: updated analysis of a prospective series of 2217 cases

Fig. 13

Analysis of DNA polymorphic markers (microsatellites) demonstrates that the DNA pattern from villous tissue is consistent with triploidy. None of the markers demonstrates two unique (paternal) alleles (PCR product peak without arrow). All informative markers demonstrate a pattern consistent with an additional maternal chromosome complement (PCR product peak with bidirectional arrow) with paternal:maternal ratio 1:2, consistent with digynic triploidy.

Back to article page