Table 1 Age information, p57 immunohistochemistry, and molecular genotyping in 2217 cases.

	CHM (570)	PHM (497)	NM (900)	Mosaics (56)	Ectopic (57)	Nondefinitive (137)
Age (years)
Mean	30.3	29.9	32.1	30.2	30.0	31.9
Median	29	30	32	30	29	32
Range	12–64	13–45	13–49	16–45	18–44	17–47
P57
Positive	1^a	481	887	0	54	121
Negative	553^b	5^c	2^d	0	1	8^e
Discordant	0	0	0	19	0	2^e
Divergent	10^f	0	0	37	0	0
Unsatisfactory	5^e	10^e	10^e	0	2^e	6^e
Not performed	1	1	1	0	0	0
STR genotyping
Androgenetic	148	–	–	–	–	1 ^g
Diandric triploidy	–	484	–	–	1	0
Triandric tetraploidy	–	13	–	–	–	–
Digynic triploidy	–	–	19	–	–	–
Biparental	5^h		851	–	33	9
Androgenetic/biparental (no molar component)	–	–	–	13	–	–
Androgenetic/biparental (with androgenetic molar component)	–	–	–	16	–	–
Complex/problematic				2
Unsatisfactory	4ⁱ	–	–	–	1ⁱ	33ⁱ
Not performed	413	–	30	25	22	94

CHM complete hydatidiform mole, PHM partial hydatidiform mole, NM nonmolar, STR short tandem repeat.
^aAndrogenetic conception with retained maternal chromosome 11.
^bIncludes four multiple gestations with a p57-negative CHM component; includes 28 invasive CHMs.
^cThree with loss of maternal chromosome 11 and two with unknown mechanisms.
^dNo features of familial biparental CHM; one with Beckwith–Wiedemann syndrome and one with unknown mechanisms accounting for negative p57.
^eDegenerative villi.
^fTen cases of multiple gestations with p57-negative CHM component and p57-positive nonmolar component; four additional cases of twin CHM with term placenta not assessed for p57.
^gThe histologic appearance was not suggestive of a CHM.
^hFour patients, with a total of nine specimens, including five genotyped CHMs with typical morphology, negative p57 immunostaining, and biparental genotypes, probably representing familial recurrent CHMs.
ⁱGenotyping unsatisfactory due to insufficient villi, villi being too intimately admixed with decidua, no decidua, unsuccessful PCR amplification, or complex genotypes.

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