Table 1 Immunohistochemical (IHC) expression of HER2, ERBB2 amplification status determined by FISH and combined IHC/FISH assays in cases of uterine serous carcinoma compared to ERBB2 copy number as determined by next-generation sequencing (NGS).

From: Detection of ERBB2 amplification in uterine serous carcinoma by next-generation sequencing: an approach highly concordant with standard assays

 

ERBB2 copy number by NGS

 

<6

≥6

HER2 IHC

 0

44

0

 1+

25

1

 2+

16

3

 3+

0

4

ERBB2 FISH interpretation

 Negative

18

0

 Positive

0

6

HER2 IHC/FISH combined interpretation

 Negative

85

0

 Positive

0

8

Back to article page