Table 5 Scoring criteria for PD-L1 immunohistochemistry in triple negative breast cancer.
From: Novel uses of immunohistochemistry in breast pathology: interpretation and pitfalls
Immune cell (IC) score = percentage of tumor area occupied by PD-L1+ immune cells | |
|---|---|
Definition caveats | Tips to avoid pitfalls |
Immune cells = all immune cells (including lymphocytes, neutrophils, and macrophages) | Exclude immune cells outside of the tumor area |
Percentage = percentage of tumor area occupied by PD-L1+ IC, not the percentage of PD-L1+ IC | Exclude nonspecific labeling in necrosis and other compartments |
Exclude nonspecific precipitate | |
Exclude tumor cell labeling | |
