Fig. 2: Flowchart indicating the process of case selection and exclusion, as well as broad outcome of mutational analyses. | Modern Pathology

Fig. 2: Flowchart indicating the process of case selection and exclusion, as well as broad outcome of mutational analyses.

From: Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice

Fig. 2

All orders for the MPS lymphoma panel were collected for the defined study period. Canceled orders (64) were removed prior to case analysis, yielding 534 cases that were processed. Of the cases processed, 40 were either quantitatively or qualitatively insufficient for sequencing and of the sequenced cases, 23 were not representative of mature lymphoid neoplasms. Ultimately, 471 sequenced cases were analyzed of which 51.2% had detectable DAVs, 17.8% had VUSs only detected, and 31% had no variants (NV) detected. The latter cases with no variants detected were further stratified by the presence or absence of a mature lymphoid neoplasm in the specimen. Approximately one-third of the cases (49/146) with no variants (NV) detected had no disease present.

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