Table 2 Categorization of MPS results in each diagnostic category.

From: Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice

Diagnostic category

Subcategory

Cases

DAV

VUS

NV

QTF

QLF

B-cell neoplasms

Diffuse large B-cell lymphoma

116

79

11

16

8

2

Chronic lymphocytic leukemia

60

37

7

15

1

–

Marginal zone lymphoma

52

25

10

14

–

3

Follicular lymphoma

43

27

11

3

1

1

Mantle cell lymphoma

28

11

6

6

4

1

High grade B-cell lymphoma

14

9

3

–

2

–

Lymphoplasmacytic lymphoma

12

10

1

1

–

–

Immunodeficiency associated lymphomas

10

5

3

1

1

–

B-cell neoplasm, miscellaneousa

6

5

–

1

–

–

T-cell neoplasms

Variousb

40

18

8

13

–

1

Other

Atypical lymphoproliferationsc

39

3

7

18

6

5

Lymphoma, NOSd

30

9

8

9

2

2

No disease

 

61

3

9

49

–

–

  1. QTF quantitative failure (insufficient amounts of DNA), QLF qualitative failure (inadequate DNA quality).
  2. aB-cell neoplasm, miscellaneous includes the following diagnoses: hairy cell leukemia; hairy cell leukemia variant; plasmablastic lymphoma; and Burkitt lymphoma.
  3. bT-cell neoplasms, various includes: angioimmunoblastic T-cell lymphoma; anaplastic large cell lymphoma; subcutaneous panniculitis-like T-cell lymphoma; nodal involvement by Sezary syndrome; adult T-cell leukemia/lymphoma; peripheral T-cell lymphoma, not otherwise specified; peripheral T-cell lymphoma with T-follicular helper features; cutaneous T-cell lymphoma; T-cell large granular lymphocytic leukemia; large granular lymphocytosis; T-prolymphocytic leukemia; extranodal NK/T-cell lymphoma, nasal type; and follicular T-cell lymphoma.
  4. cAtypical lymphoproliferations include the following descriptive terminologies: atypical lymphoid proliferation, not otherwise specified; atypical T-cell infiltrate; atypical B-cell infiltrate; EBV+ lymphoproliferative disorder; and CD30+ T-cell lymphoproliferative disorder.
  5. dLymphoma, NOS (not otherwise specified) includes nonspecific diagnoses such as: lymphoid neoplasm with plasma cell differentiation; low-grade B-cell lymphoma CD5− CD10−; lymphoplasmacytic lymphoma vs. marginal zone lymphoma; B-cell lymphoma of germinal center origin; CD10+ B-cell neoplasm; CD5+ B-cell lymphoma; non-Hodgkin B-cell lymphoma; aggressive mature B-cell lymphoma; mature CD4+ T-cell lymphoma; T-cell neoplasm of T-follicular helper cell origin; B-lymphoblastic lymphoma with MYC and BCL2 rearrangement; and CD5+ B-cell clone.
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