Fig. 1: Histopathologic appearances of selected cases of GCA with associated genetic alterations. | Modern Pathology

Fig. 1: Histopathologic appearances of selected cases of GCA with associated genetic alterations.

From: Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations

Fig. 1

a GCA-011. Adenocarcinoma with clear and vacuolated cytoplasm, associated with peritumoral lymphocytes; no mutations identified (hematoxylin-eosin, ×100). b GCA-018. Adenocarcinoma with clear and vacuolated cytoplasm, associated with scant tumor-infiltrating lymphocytes; TP53 hotspot mutation with loss-of-heterozygosity (hematoxylin-eosin, ×100). c GCA-111. Gastric-type adenocarcinoma in situ, with clear and vacuolated cytoplasm; CDKN2A hotspot mutation (hematoxylin-eosin, ×100). d GCA-022. Adenocarcinoma with focally clear cytoplasm, without peritumoral lymphocytes; KRAS hotspot mutation with loss-of-heterozygosity (hematoxylin-eosin, ×100). e GCA-012. Gastric-type adenocarcinoma in situ, with clear and vacuolated cytoplasm; STK11 truncating SNV (hematoxylin-eosin, ×100). f GCA-019. Adenocarcinoma with ERBB3 missense SNV with loss-of-heterozygosity (hematoxylin-eosin, ×100). g GCA-002. Adenocarcinoma with GNAS hotspot mutation. (hematoxylin-eosin, ×100). h GCA-102. Adenocarcinoma associated with patchy peritumoral lymphocytes; TP53 hotspot mutation with CDKN2A SNV (hematoxylin-eosin, ×100). i GCA-037. Adenocarcinoma with foamy cytoplasm, associated with tumor-infiltrating and peritumoral lymphocytes; CDKN2A hotspot mutation with STK11 SNV (hematoxylin-eosin, ×100). j GCA-015. Adenocarcinoma with foamy cytoplasm, associated with peritumoral lymphocytes and neutrophils; ERBB3 and ERBB2 hotspot mutations (hematoxylin-eosin, ×100). j GCA-110. Adenocarcinoma with KRAS and GNAS hotspot mutations (hematoxylin-eosin, ×100).

Back to article page