Fig. 3: DNA copy number alterations in 68 GCAs. | Modern Pathology

Fig. 3: DNA copy number alterations in 68 GCAs.

From: Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations

Fig. 3

DNA copy number alterations in 68 GCAs subjected to targeted massively parallel sequencing showed that most tumors displayed low levels of copy number alterations; the median fraction of genome altered was 6.1% (range, 0–67%). While no recurrent high-level amplifications or homozygous deletions were detected, individual cases displayed amplifications in genes such as CCND1, MYC, and ERBB2. A subset of cases showed no copy number alterations or non-synonymous mutations. Chromosomes are shown along the x-axis, and cases along the y-axis. Homozygous deletions, dark blue; losses, light blue; gains, orange; amplifications, red.

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