Table 1 Histopathologic features of 68 GCAs.

From: Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations

Sample ID

TILs

Peritumoral lymphocytes

Neutrophils

Mitoses per 10 HPF

Apoptoses per 10 HPF

Additional findings and comments

GCA-001

     

Small amount of tumor

GCA-002

(+)

1

5

 

GCA-004

     

Small amount of tumor

GCA-006

     

Small amount of tumor

GCA-007

     

Small amount of tumor

GCA-008

2

6

GCA involving bowel

GCA-009

1

3

Bizarre nuclear atypia

GCA-010

     

Small amount of tumor

GCA-011

+, 1

1

2

 

GCA-012

     

Small amount of tumor

GCA-014

+, 2

7

4

 

GCA-015

+, 2

+

2

1

 

GCA-016

+

+, (1)

+

1

8

 

GCA-017

+, (1)

1

2

 

GCA-018

+

+, (1)

(+)

49

58

 

GCA-019

+, (1)

3

27

 

GCA-020

+

+

0

5

 

GCA-024

(+)

+, 2

+

4

6

 

GCA-025

+

+, 2

+

11

5

 

GCA-026

+

+, 1

+

4

4

 

GCA-027

(+)

+

0

0

Small amount of tumor

GCA-028

+, (1)

(+)

1

4

 

GCA-029

-

(+)

5

7

 

GCA-030

+

+, 1

+

13

13

 

GCA-031

+

+, (1)

10

2

 

GCA-032

+

+, 1

0

14

Extensive gAIS

GCA-033

(+)

 

26

16

Metastatic GCA involving lymph node

GCA-034

+

+, (1)

0

0

 

GCA-035

7

13

 

GCA-036

+, (1)

7

7

 

GCA-037

+

+, 1

+

2

3

 

GCA-039

+

3

6

Metastatic GCA involving lymph node

GCA-041

4

6

 

GCA-042

+

0

0

 

GCA-043

+

+

3

6

 

GCA-044

+

3

0

 

GCA-045

+

+

3

4

Extensive gAIS and LEGH

GCA-046

     

Small amount of tumor

GCA-047

     

Small amount of tumor

GCA-048

+

2

0

 

GCA-049

+

2

12

 

GCA-050

+

4

2

 

GCA-102

+, (1)

+

4

8

 

GCA-104

(+)

9

6

 

GCA-105

(+)

+, (1)

+, dense

12

4

Exuberant desmoplasia

GCA-106

(+)

+, (1)

8

4

 

GCA-107

+

+, (1)

11

6

 

GCA-108

(+)

+, (2)

4

5

 

GCA-109

(+)

5

2

 

GCA-110

1

3

Extensive LEGH and focal gAIS

GCA-112

6

46

 

GCA-113

(+)

+, (1)

7

4

 

GCA-115

+, (1)

+

6

5

Associated extensive lymphovascular invasion and LEGH

GCA-116

+

+, 2

+

26

8

 

GCA-117

+

+, 2

8

0

 

GCA-118

     

Extensive gAIS with focal invasion + associated LEGH

GCA-119

+

+

+

4

9

Extensive lymphovascular invasion

GCA-120

+, (2)

(+)

1

1

 

GCA-121

+, (1)

+, dense

3

4

 

GCA-122

+

14

2

 

GCA-123

+, (1)

+

1

7

 

GCA-124

1

5

 

GCA-125

+

+, (1)

+

5

7

 

GCA-127

(+)

+, 2

+, dense

3

12

 

GCA-128

+

6

0

 

GCA-129

+, (1)

1

2

 

GCA-130

+, 2

+, dense

3

2

 

GCA-131

24

4

 

GCA-132

+

+, 3

+

10

9

 
  1. TILs—tumor-infiltrating lymphocytes: + present; (+) rare; − absent.
  2. Peritumoral lymphocytes: + present; +, 1 mild, diffuse; +, (1) mild, patchy; +, 2 moderate, diffuse; +, (2) moderate, diffuse; +, 3 marked, diffuse; − absent.
  3. Neutrophils: + present; (+) rare; − absent.
  4. GCA gastric-type cervical adenocarcinoma, HPF high-power field, LEGH lobular endocervical glandular hyperplasia, gAIS gastric-type adenocarcinoma in situ.