Fig. 3: Histopathologic findings of invasive carcinoma. | Modern Pathology

Fig. 3: Histopathologic findings of invasive carcinoma.

From: Conjunctival ‘mucoepidermoid carcinoma’ revisited: a revision of terminology, based on morphologic, immunohistochemical and molecular findings of 14 cases, and the 2018 WHO Classification of Tumours of the Eye

Fig. 3

a Case 4. H&E showing invasive basaloid variant SCC. Note the ribbons of basaloid cells with focal tumour necrosis (arrow). b Case 7. H&E showing typical invasive keratinising SCC. c Case 7. H&E. The arrow points to occasional goblet-cell like intracytoplasmic mucin deposits. d Case 7 Alcian blue (AB) stain, showing blue intracytoplasmic mucin deposits, confirming the diagnosis of invasive SCC with mucinous differentiation. e Case 9 H&E. The arrow points to invasive carcinoma arising from in-situ carcinoma indicated by the asterisk. f Case 9 H&E higher magnification showing signet ring-like spaces (arrows) in amongst non-keratinising SCC. g Case 9 AB stain showing that the signet ring-like spaces contain mucin, indicating a diagnosis of SCC with mucinous differentiation. h Case 11 H&E. The arrow points to the invasive adenocarcinoma part and the asterisk indicates the invasive SCC in this example of ASC. i Case 11 H&E showing the adenocarcinoma component that is well-differentiated, with back-to back neoplastic glands that contain eosinophilic secretion. j Case 11 H&E showing the non-keratinizing invasive SCC component. Note the ample pink cytoplasm. k Case 11 combined AB/Periodic acid Schiff stain showing pink mucin produced by the adenocarcinoma. l Case 12 H&E. This shows the keratinising SCC component (arrow points to keratin). m Case 12 H&E showing the confluent area of glandular differentiation component (arrow). n Case 14 H&E showing neoplastic glands only without a squamous carcinoma component. o Case 14 AB stain. This shows prominent mucin produced by the adenocarcinoma.

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