Fig. 4: Immunohistochemical findings of invasive carcinoma. | Modern Pathology

Fig. 4: Immunohistochemical findings of invasive carcinoma.

From: Conjunctival ‘mucoepidermoid carcinoma’ revisited: a revision of terminology, based on morphologic, immunohistochemical and molecular findings of 14 cases, and the 2018 WHO Classification of Tumours of the Eye

Fig. 4

a Case 6. The morphological diagnosis was SCC with mucinous differentiation. CK7 stains an area with goblet cells. b Case 6. The same area as plate a showing peripheral CK17 staining of areas with squamous differentiation. c Case 6. Ki-67 showing around 50% proliferation fraction. d Case 6 showing p16 block positivity. e Case 11 where the morphological diagnosis was ASC. CK7 stains the adenocarcinoma component whereas the SCC component indicated by the asterisk is negative. f Case 11. CK17 stains the SCC component and was negative on the adenocarcinoma component (not shown as adenocarcinoma component was cutting out of section). g Case11. BerEP4 staining of the SCC component. h Case 11. Ki-67 staining of the SCC component. i Case 11. p16 stains the adenocarcinoma component and not the SCC component. j Case 14 where the morphological diagnosis was adenocarcinoma. This is the CK7 staining pattern showing strong staining in the neoplastic glands. k Case 14. CK17 showing staining of the edges of the neoplastic glands. l Case 14. BerEP4 showing staining of the neoplastic mucin-containing cells.

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