Fig. 4: ERBB2 alterations. | Modern Pathology

Fig. 4: ERBB2 alterations.

From: Genomic profiling of pleomorphic and florid lobular carcinoma in situ reveals highly recurrent ERBB2 and ERRB3 alterations

Fig. 4

ERRB2 and/or ERBB3 alterations were observed in all but one case (a), with two or more concurrent alterations in a subset. ERBB2 mutations were predominantly missense mutations found within the protein tyrosine kinase and furin-like extracellular domains and predicted to be activating (b). Amp amplification, Mut mutation, ECD extracellular domain, TM transmembrane region, PTK protein tyrosine kinase.

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