Fig. 4: Structure and breakpoints of THBS1-ADGRF5 fusions.
From: Recurrent novel THBS1-ADGRF5 gene fusion in a new tumor subtype “Acral FibroChondroMyxoid Tumors”
The left panel shows the location of THBS1 and ADGRF5 loci and orientation of each genes. The right panel illustrates the cDNA sequence of the most common fusion, involving exon 21 of THBS1 and exon 12 of ADGRF5. Arrows indicate the break-point for each gene (a). Schematic representation of the structure of the respective proteins. The dotted lines indicate the location of the breakpoints in the domain and the structure of the chimeric THBS1-ADGRF5 protein is shown below, with the theoretically retained domains (b). GPS GPCR proteolytic site motif, Ig-like immunoglobulin-like domain, VWFD Von Willebrand Factor domain, EGF epidermal growth factor.
