Fig. 6: Melanoma with adjacent lymphocytic inflammation from the IHC-test set. | Modern Pathology

Fig. 6: Melanoma with adjacent lymphocytic inflammation from the IHC-test set.

From: A machine learning algorithm for simulating immunohistochemistry: development of SOX10 virtual IHC and evaluation on primarily melanocytic neoplasms

Fig. 6

a Hematoxylin and eosin (H&E) stains, along with corresponding b SOX10 immunohistochemistry (IHC) performed on the same tissue layer. c SOX10 virtual immunohistochemistry (vIHC) was performed using the H&E image as an input. Lymphocytes that were erroneously labeled as SOX10-positive by the vIHC are shown (white arrows). Notably, artifacts that will be found in slides used for clinical care, such as dotting marks, do not appear to have a significant adverse effect on the neural network in this case.

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