Fig. 2: Gradual transition between low- and high-grade components of endometrial stromal sarcoma. | Modern Pathology

Fig. 2: Gradual transition between low- and high-grade components of endometrial stromal sarcoma.

From: High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities

Fig. 2

a A low-grade component composed of cells with small hyperchromatic nuclei and scant eosinophilic cytoplasm (left) merges with a high-grade component composed of cells with slightly larger nuclei, open chromatin, prominent nucleoli, and increased amphophilic cytoplasm (right). b Dense proliferation of small spindle cells typical of LGESS (left) to a high-grade component with increased cytologic atypia (right).

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