Fig. 3: Paired foci of high- and low-grade components. | Modern Pathology

Fig. 3: Paired foci of high- and low-grade components.

From: High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities

Fig. 3

High-grade components are composed of enlarged epithelioid cells with round nuclei, heterogeneous chromatin, and moderate amounts of amphophilic or eosinophilic cytoplasm associated with brisk mitotic activity and forming (a) trabeculae or (b), (c) sheets. Low-grade components show variant d fibrous, e myxoid, and f conventional histology.

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