Table 1 Clinicopathological features of lung adenocarcinoma with and without discohesive growth pattern (Disco-p).

From: Discohesive growth pattern (Disco-p) as an unfavorable prognostic factor in lung adenocarcinoma: an analysis of 1062 Japanese patients with resected lung adenocarcinoma

 

n

Disco-p+

Disco-p−

p value

Total

1062

203

859

 

Age

 ≤65

435

85

350

0.770

 ≥66

627

118

509

Sex

 Male

515

129

386

<0.001

 Female

547

74

473

Smoking

 Smoker

561

138

423

<0.001

 Never smoker

501

65

436

Tumor size

 ≤25 mm

703

98

605

<0.001

 >25 mm

359

105

254

pN

 0

904

125

779

<0.001

 1, 2

158

78

80

Stage

 0

21

0

21

<0.001

 I

832

107

725

 II

111

46

65

 III

98

50

48

2015 WHO classification

 AIS

21

0

21

<0.001

 MIA

123

0

123

 Lepidic ADC

109

1

108

 Acinar ADC

115

30

85

 Papillary ADC

459

61

398

 Solid ADC

154

94

60

 MP ADC

35

14

21

 IMA

41

3

38

 Other ADC

5

0

5

Tumor grade

 Well differentiated

304

2

302

<0.001

 Moderately differentiated

450

32

418

 Poorly differentiated

308

169

139

TRU

 TRU

943

181

762

0.853

 Non-TRU

119

22

97

Pleural invasion

 PL 1-3

207

105

102

<0.001

 PL 0

855

98

757

Lymphatic invasion

 Positive

101

49

52

<0.001

 Negative

961

154

807

Vascular invasion

 Positive

194

94

100

<0.001

 Negative

868

109

759

STAS

 Positive

385

112

273

<0.001

 Negative

677

91

586

Tumor budding

 Low grade (grade 0,1)

1020

161

859

<0.001

 High grade (grade 2,3)

42

42

0

  1. AIS adenocarcinoma in situ, MIA minimally invasive adenocarcinoma, ADC adenocarcinoma, MP micropapillary, IMA invasive mucinousadenocarcinoma, TRU terminal respiratory unit, STAS spread through air spaces.