Fig. 3: Immunohistochemistry in PTC-DTF and PTC-NFS. | Modern Pathology

Fig. 3: Immunohistochemistry in PTC-DTF and PTC-NFS.

From: Papillary thyroid carcinoma with prominent myofibroblastic stromal component: clinicopathologic, immunohistochemical and next-generation sequencing study of seven cases

Fig. 3

a Immunohistochemical staining of the stromal component for beta-catenin showed nuclear and cytoplasmic staining in the spindle cells of PTC-DTF; b Small island of neoplastic epithelium showing strong membranous staining for beta-catenin in the PTC tumor cells as well as in the spindle cells in the surrounding stroma; c Spindle cells in the stroma showed cytoplasmic staining for SMA in both cases of PTC-DTF and PTC-NFS, supporting a myofibroblastic phenotype; d MIB1 immunostaining showed scattered nuclear positivity in a few of the nuclei in PTC-NFS (Case 5).

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