Table 2 Sensitivity, specificity, PPV, and NPV for each of the 28 cancer types for the hybrid model shown in Fig. 3.
From: Minimalist approaches to cancer tissue-of-origin classification by DNA methylation
Abbreviation | Sensitivity | Specificity | Pos pred value | Neg pred value | Balanced accuracy | |
|---|---|---|---|---|---|---|
Adrenocortical carcinoma | ACC | 1.000 | 1.000 | 0.960 | 1.000 | 1.000 |
Bladder urothelial carcinoma | BLCA | 0.895 | 0.995 | 0.902 | 0.995 | 0.945 |
Breast invasive carcinoma | BRCA | 0.979 | 0.997 | 0.970 | 0.998 | 0.988 |
Cervical and endocervical cancers | CESC | 0.848 | 0.996 | 0.886 | 0.994 | 0.922 |
Cholangiocarcinoma | CHOL | 0.727 | 1.000 | 1.000 | 0.999 | 0.864 |
Colorectal adenocarcinoma | CORE | 0.975 | 0.999 | 0.983 | 0.999 | 0.987 |
Diffuse large B-cell lymphoma | DLBC | 0.867 | 0.999 | 0.867 | 0.999 | 0.933 |
Esophageal carcinoma | ESCC | 0.333 | 1.000 | 1.000 | 0.992 | 0.667 |
Glioma | GBMLGG | 0.995 | 1.000 | 1.000 | 1.000 | 0.997 |
Gastric/esophageal carcinoma | GEAD | 0.966 | 0.997 | 0.952 | 0.998 | 0.981 |
Head and neck squamous cell carcinoma | HNSC | 0.918 | 0.986 | 0.816 | 0.995 | 0.952 |
Pan-kidney cohort | KIPAN | 0.975 | 0.999 | 0.985 | 0.998 | 0.987 |
Acute myeloid leukemia | LAML | 1.000 | 1.000 | 0.983 | 1.000 | 1.000 |
Liver hepatocellular carcinoma | LIHC | 0.982 | 0.999 | 0.974 | 0.999 | 0.991 |
Lung adenocarcinoma | LUAD | 0.993 | 0.999 | 0.979 | 1.000 | 0.996 |
Lung squamous cell carcinoma | LUSC | 0.793 | 0.993 | 0.830 | 0.991 | 0.893 |
Mesothelioma | MESO | 0.889 | 1.000 | 1.000 | 0.999 | 0.944 |
Pancreatic adenocarcinoma | PAAD | 0.875 | 0.998 | 0.907 | 0.997 | 0.937 |
Pheochromocytoma and paraganglioma | PCPG | 0.944 | 0.999 | 0.962 | 0.999 | 0.972 |
Prostate adenocarcinoma | PRAD | 1.000 | 0.999 | 0.987 | 1.000 | 1.000 |
Sarcoma | SARC | 0.962 | 0.996 | 0.884 | 0.999 | 0.979 |
Skin cutaneous melanoma | SKCM | 0.813 | 1.000 | 0.963 | 0.998 | 0.906 |
Testicular germ cell tumor | TGCT | 1.000 | 0.999 | 0.938 | 1.000 | 0.999 |
Thyroid carcinoma | THCA | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
Thymoma | THYM | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
Uterine corpus endometrial carcinoma | UCEC | 0.954 | 0.994 | 0.892 | 0.998 | 0.974 |
Uterine carcinosarcoma | UCS | 0.778 | 1.000 | 0.933 | 0.998 | 0.889 |
Uveal melanoma | UVM | 1.000 | 1.000 | 0.960 | 1.000 | 1.000 |
