Fig. 1: Cancerization of ducts (COD), or intraductal spread of invasive ductal adenocarcinoma.

The black dotted line indicates the abrupt transition from intraductal pancreatic ductal adenocarcinoma (PDAC) cells to normal duct epithelium. Hematoxylin & eosin (H&E)-stained section; original magnification, 400×.