Fig. 1: Representative histological images and survival analyses of gastric MANECs. | Modern Pathology

Fig. 1: Representative histological images and survival analyses of gastric MANECs.

From: Chromosomal and molecular pathway alterations in the neuroendocrine carcinoma and adenocarcinoma components of gastric mixed neuroendocrine–nonneuroendocrine neoplasm

Fig. 1

a H&E staining (100×) showed the separated NEC (arrow) and adenocarcinoma (cross-shape) components. Immunohistochemistry staining (100×) showed positive Syn expression only in the NEC component and positive CK8/18 expression in both the NEC and adenocarcinoma components. Ki-67 indicated the cell proliferation activity of both tumor components. b Univariate survival analyses of PFS and OS in 34 cases of gastric MANEC. MANEC mixed adenoneuroendocrine carcinoma, H&E hematoxylin and eosin, NEC neuroendocrine carcinoma, PFS progression-free survival, OS overall survival, LN lymph node.

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