Fig. 4: Clustering analysis of the eight gastric MANECs and representative histological images of different kinds of cases. | Modern Pathology

Fig. 4: Clustering analysis of the eight gastric MANECs and representative histological images of different kinds of cases.

From: Chromosomal and molecular pathway alterations in the neuroendocrine carcinoma and adenocarcinoma components of gastric mixed neuroendocrine–nonneuroendocrine neoplasm

Fig. 4

a Clustering analysis showed that adenocarcinoma components in different cases tended to be grouped, except in cases 1 and 3, while the NEC components in different cases were not clustered. b Histological images of case 3 with the two tumor components clustered. Although H&E staining (100×) showed the separated NEC (arrow) and adenocarcinoma (cross-shape) components, the immunohistochemistry staining of CgA (200×) demonstrated that neuroendocrine carcinoma cells (triangle) were scattered in the adenocarcinoma area. c Histological images of case 4 with the two tumor components not clustered. H&E staining (100×) showed the separated NEC (arrow) and adenocarcinoma (cross-shape) components, and immunohistochemistry staining of CD56 (100×) indicated that CD56-positive cells were only located in the NEC area.

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