Fig. 5: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for the NEC components of eight gastric MANECs. | Modern Pathology

Fig. 5: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for the NEC components of eight gastric MANECs.

From: Chromosomal and molecular pathway alterations in the neuroendocrine carcinoma and adenocarcinoma components of gastric mixed neuroendocrine–nonneuroendocrine neoplasm

Fig. 5

The proteins related to the genes located in the CNV regions specific for the NEC component were enriched and were present in the top 100 results of the protein–protein interaction analysis. Pathways including MAPK signaling, cell cycle, oxytocin signaling, Rap1 signaling, extracellular matrix-receptor interaction, tyrosine metabolism, and p53 signaling are highlighted. Octagonal nodes represent the pathway, and circular nodes represent the genes. The magnitude of the octagonal nodes represents the extent to which the pathways are enriched. The circular nodes with black borders represent copy number loss, and those without borders represent copy number gain.

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