Table 1 The clinicopathologic characteristics of 35 patients with gastric MANEC and the univariate survival analyses of PFS and OS.
Characteristic | n (%) | P value for PFSa | P value for OSa |
|---|---|---|---|
Age at diagnosis | 0.254 | 0.190 | |
<60 years old | 15 (42.9) | ||
≥60 years old | 20 (57.1) | ||
Sex | 0.737 | 0.700 | |
Male | 29 (82.9) | ||
Female | 6 (17.1) | ||
Location | 0.489 | 0.094 | |
Cardia–fundus | 14 (40.0) | ||
Gastric body | 10 (28.6) | ||
Antrum-pylorus | 8 (22.9) | ||
Multiple sites in stomach | 2 (5.7) | ||
Remnant stomach | 1 (2.9) | ||
Size (median) | 0.070 | 0.407 | |
<5 cm | 17 (48.6) | ||
≥5 cm | 18 (51.4) | ||
Ki-67 index of NEC component | 0.079 | 0.018 | |
<50% | 8 (22.9) | ||
≥50% | 27 (77.1) | ||
Lymph node metastasis | 0.039 | 0.012 | |
Negative | 12 (34.3) | ||
Positive | 23 (65.7) | ||
Intravascular carcinoma thrombus | 0.325 | 0.407 | |
Negative | 23 (65.8) | ||
Positive | 12 (34.3) | ||
Nerve invasion | 0.472 | 0.827 | |
Negative | 22 (62.9) | ||
Positive | 13 (37.1) | ||
Distant metastasis | 0.025 | 0.014 | |
Negative | 30 (85.7) | ||
Positive | 5 (14.3) | ||
Stage | 0.048 | 0.007 | |
I/II | 12 (34.3) | ||
III/IV | 23 (65.7) | ||
Adjuvant therapy | 0.181 | 0.226 | |
No | 9 (26.5) | ||
Yes | 25 (73.5) | ||
Adjuvant therapy in stage I/II | 0.456 | 0.414 | |
No | 5 (14.7) | ||
Yes | 6 (17.6) | ||
Adjuvant therapy in stage III/IV | 0.650 | 0.590 | |
No | 4 (11.8) | ||
Yes | 19 (55.9) | ||
Recurrence and/or metastasis during follow-upa | – | <0.001 | |
No | 15 (42.9) | ||
Yes | 19 (54.3) |
