Fig. 2: JAM-A protein expression is a biomarker of favorable outcome in the discovery cohort. | Modern Pathology

Fig. 2: JAM-A protein expression is a biomarker of favorable outcome in the discovery cohort.

From: Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa

Fig. 2

a Representative images of tissue staining corresponding to the first, 25th, 50th, 75th, and 99th percentiles of JAM-A levels in tumor epithelial tissue obtained by DIA. Large images show DAPI (blue) and JAM-A (red) staining. Inset images show DAPI (blue), JAM-A (red), and KRTs (yellow) staining to visualize epithelial structures. b Correlation of JAM-A levels between duplicate tissues for each tumor (n = 101). Spearman Rho and p value are indicated. c JAM-A staining in fallopian tube and HGSC tissues. Large images show DAPI (blue) and JAM-A (red) staining. Inset images show DAPI (blue), JAM-A (red), and KRTs (yellow) staining to visualize epithelial structures. Higher magnifications of the highlighted region are shown (right)—DAPI, JAM-A and KRTs (top), and DAPI and JAM-A (bottom). Arrows indicate JAM-A staining at the apical pole of fallopian tube epithelial cells. d JAM-A protein level in HGSC (n = 101) and fallopian tube (n = 15) tissues from the discovery TMA. Each point represents the mean JAM-A level stained in duplicate. e Kaplan–Meier curves of JAM-A dichotomized into low and high JAM-A expression for progression-free survival (left) and overall survival (right). Log rank p value is indicated. Number of patients and median number of survival months are indicated for each group.

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