Fig. 2

Diffuse malignant peritoneal mesothelioma with BAP1 alterations a Peritoneal mesothelioma (patient #7) with BAP1 nonsense mutation showed b complete loss of BAP1 expression by immunohistochemistry. c Schematics illustrating the locations of mutations in BAP1 identified in our study (patients #1–3, #5, #7, #13–15, #18; excluding rearrangements/deletion). UCH: ubiquitin carboxy-terminal hydroxylase domain. BA: BARD1-binding domain. BR: BRCA1-binding domain. H: HCF1-binding domain. NLS: nuclear localization sequence. d Copy number VisCap plot of peritoneal mesothelioma (patient #12) with two-copy loss of BAP1 at 3p21 (red arrow). e Copy number VisCap plot of peritoneal mesothelioma (patient #16) with one-copy loss of BAP1 at 3p21 (red arrow) and two-copy loss of CDKN2A at 9p21 (blue arrow).