Table 2 Summary of molecular alterations in epithelioid-type diffuse malignant peritoneal mesothelioma.
From: Molecular characterization of diffuse malignant peritoneal mesothelioma
Gene with alterations | Total epithelioid cohort (n = 23) | BAP1-altered (n = 17) | BAP1-wild-type (n = 6) | ||||
|---|---|---|---|---|---|---|---|
Number | % | Number | % | Number | % | p value | |
BAP1 | 17 | 73.9 | 17 | 100.0 | 0 | 0.0 | |
PBRM1a | 11 | 55.0 | 11 | 73.3 | 0 | 0.0 | 0.008 |
SETD2 | 8 | 34.8 | 8 | 47.1 | 0 | 0.0 | 0.058 |
NF2 | 4 | 17.4 | 3 | 17.6 | 1 | 16.7 | 1.000 |
TP53 | 3 | 13.0 | 2 | 11.8 | 1 | 16.7 | 1.000 |
TSC1 | 3 | 13.0 | 2 | 11.8 | 1 | 16.7 | 1.000 |
TSC2 | 3 | 13.0 | 2 | 11.8 | 1 | 16.7 | 1.000 |
LIG4b | 1 | 6.3 | 1 | 7.7 | 0 | 0.0 | 0.427 |
ERCC6b | 1 | 6.3 | 1 | 7.7 | 0 | 0.0 | 0.427 |
SUZ12 | 1 | 4.3 | 0 | 0.0 | 1 | 16.7 | 0.261 |
TRAF7b | 1 | 6.3 | 0 | 0.0 | 1 | 33.3 | 0.188 |
ALK | 2 | 8.7 | 0 | 0.0 | 2 | 33.3 | 0.059 |
ARID1B | 13 | 56.5 | 11 | 64.7 | 2 | 33.3 | 0.341 |
PRDM1 | 13 | 56.5 | 11 | 64.7 | 2 | 33.3 | 0.341 |
CDKN2A | 4 | 17.4 | 4 | 23.5 | 0 | 0.0 | 0.539 |
CDKN2B | 4 | 17.4 | 4 | 23.5 | 0 | 0.0 | 0.539 |
Genomic near-haploidization | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | NA |
