Fig. 2: Timeline for widely metastatic malignant chondroblastoma (case 1).
The long axis represents time, with time at initial presentation designated “t = 0;” events are described below the axis, and the time elapsed since initial presentation is shown above the axis for each event. This patient presented with a rib mass at 49 years of age and developed recurrence and metastases over a long time period, dying 27.5 years after initial presentation with a likely cerebellar metastasis (not biopsied). The tumor in this case had lymphovascular invasion as well as a mitotic rate of up to 15 mitoses per 2 mm2, a much higher mitotic rate than the other malignant chondroblastomas in this series. The course of disease in this patient calls into question the notion that chondroblastoma is a uniformly benign neoplasm.
