Fig. 1: OncoPrint plot showing mutations found in the chRCC tumors together with IHC stainings. | Modern Pathology

Fig. 1: OncoPrint plot showing mutations found in the chRCC tumors together with IHC stainings.

From: Molecular characterization of chromophobe renal cell carcinoma reveals mTOR pathway alterations in patients with poor outcome

Fig. 1

The matrix shows the 92 primary tumors analyzed in the series. The upper rows indicate characteristics of the cases (stage, metastasis, survival outcome, and eosinophilic variant). The rows in the middle panels show mutations colored according to the variant impact (high or moderate);  black boxes denote cases with multiple mutations in the gene. Those variants with an allele fraction (AF) above 0.60 are depicted by long bars, while lower frequencies are represented by squares. Mitochondrial DNA mutations are shown in pink. The last panel shows IHC results for phospho-S6 (S235/236), PTEN, tuberin, and p53 proteins. Colors indicate different IHC staining categories (blue–brown) as defined in “Methods” section.

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