Table 3 Multivariable proportional hazards regression analysis comparison for the three tumor groupsa.

From: T3 versus T4a staging challenges in deeply invasive colonic adenocarcinomas and correlation with clinical outcomes

Outcome

Cohort

Overall p valueb

Hazard ratios and 95% confidence intervals

Group 1 versus 3

Group 2 versus 3

Group 1 versus 2

Recurrence

Entire cohort

0.005

3.3 (1.31–8.30)

4.1 (1.73–9.54)

0.8 (0.58–2.59)

Survival

Entire cohort

<0.001

8.1 (3.97–16.56)

7.3 (3.67–14.49)

1.1 (0.68–1.83)

Recurrence

Lymph node negative

0.004

10.7 (2.66–43.37)

5.0 (1.26–20.13)

2.1 (0.69–6.61)

Survival

Lymph node negative

<0.001

17.4 (6.31–48.13)

7.2 (2.51–20.53)

2.4 (1.15–5.11)

  1. aGroup 1—T4a colonic adenocarcinoma at the serosal surface; Group 2—Deeply invasive colonic adenocarcinoma ≤1 mm from the serosal surface; Group 3—T3 colonic adenocarcinoma >1 mm from the serosal surface.
  2. bAdjusted for adjuvant therapy and number of positive lymph nodes for entire cohort, adjusted for adjuvant therapy among lymph node-negative subset.
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