Fig. 5: Immunophenotype of gastrointestinal mesenchymal tumors with NTRK rearrangements. | Modern Pathology

Fig. 5: Immunophenotype of gastrointestinal mesenchymal tumors with NTRK rearrangements.

From: Mesenchymal tumors of the gastrointestinal tract with NTRK rearrangements: a clinicopathological, immunophenotypic, and molecular study of eight cases, emphasizing their distinction from gastrointestinal stromal tumor (GIST)

Fig. 5

a A proliferation of bland spindle cells with palely eosinophilic cytoplasm and occasional perinuclear vacuoles may raise a morphological diagnosis of GIST (case 5). b TRK immunohistochemistry demonstrated diffuse and strong expression in this tumor with a TPM3–NTRK1 fusion. None of the tumors in this series expressed KIT (c) or DOG1 (d).

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