Fig. 2: Plot of cumulative percentages of cases according to tumor bud counts.
From: Prognostic impact of tumor budding in endometrial carcinoma within distinct molecular subgroups

Most cases of EMCA do not show any tumor buds. Cut-off determination was therefore chosen between no versus any buds. Of note, a cut-off above two would have excluded all POLEmut cases and a cut-off of five would have over-weighted p53abn cases.