Fig. 4: Prognostication of tumor budding in molecular subtypes of EC.
From: Prognostic impact of tumor budding in endometrial carcinoma within distinct molecular subgroups
Kaplan–Meier curves of overall (a) and recurrence-free survival (b) for TCGA subgroups. Groups are defined as POLE mutated (Group 1), MMR-deficient (Group 2), p53 aberrant (Group 4), and NSMP-EMCA (Group 3); the most conventional type of EMCA sometimes referred to as the “triple-negative EMCA”. Significances could be reached for the intermediate prognostic groups. MMR-deficient Group 2 showed significant differences in overall survival (c) but not recurrence-free survival (d). The strongest impact was found for NSMP-EMCA (Group 3) in overall survival (e), as well as recurrence-free survival (f) (log-rank test).
