Fig. 2: Histological features of HPV-associated cervical adenocarcinomas with serous-like features. | Modern Pathology

Fig. 2: Histological features of HPV-associated cervical adenocarcinomas with serous-like features.

From: Cervical carcinomas with serous-like papillary and micropapillary components: illustrating the heterogeneity of primary cervical carcinomas

Fig. 2

A case of HPV-associated adenocarcinoma features complex branching papillary structures with tufted luminal borders (a) as well as high-grade nuclear atypia and frequent mitoses (b), reminiscent of serous carcinoma. Some HPV-associated cases may be predominantly exophytic and associated with adenocarcinoma in situ (c), with slit-like lumina among tumor cells over papillary structures (d). HPV-associated adenocarcinomas with micropapillary component may be accompanied by HSIL (e) and some cases may harbor tumor cells with squamoid appearance as illustrated here (f).

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