Table 3 Immunohistochemical profiles (including HER2 and PD-L1) of cervical carcinomas with serous-like features.
Case | p16 | p53 | MUC6 | CEA | PAX8 | ER | CK20 | CDX2 | GATA3 | p40 | HER2 | PD-L1 (CPS) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
HPV-associated cervical carcinomas with serous-like features (cases 1–10) | ||||||||||||
1 | + | WT | – | F | F | – | – | – | – | – | 3+ | + (1) |
2 | + | WT | F | F | – | – | F | – | – | F | 1+ | – (<1) |
3 | + | WT | – | F | F | F | – | – | – | – | 0 | + (2) |
4 | + | WT | – | D | F | – | – | – | – | – | 0 | – (0) |
5 | + | WT | – | D | D | – | – | – | – | – | 0 | – (<1) |
6 | + | WT | – | F | F | – | – | – | F | F | 1+ | + (5) |
7 | + | WT | – | F | F | – | – | – | – | – | 0 | + (10) |
8 | + | WT | F | D | F | – | – | – | – | – | 0 | – (<1) |
9 | + | WT | F | F | F | – | – | – | – | F | 2+ | NA |
10 | + | WT | – | D | F | – | – | – | F | F | 3+ | NA |
HPV-independent cervical carcinomas with serous-like features (cases 11–14) | ||||||||||||
11 | + | MT | F | F | F | – | F | D | – | – | 3+ | NA |
12 | – | WT | D | F | – | – | F | F | – | – | 0 | NA |
13 | – | WT | F | F | – | – | F | – | – | – | 0 | – (0) |
14 | – | MT | F | F | – | – | F | – | – | – | 1+ | – (0) |
