Fig. 4: Kaplan–Meier curves generated in accordance with the immune contexture and immune cell localization in patients with anorectal malignant melanoma (ARMM). | Modern Pathology

Fig. 4: Kaplan–Meier curves generated in accordance with the immune contexture and immune cell localization in patients with anorectal malignant melanoma (ARMM).

From: Distribution pattern of tumor infiltrating lymphocytes and tumor microenvironment composition as prognostic indicators in anorectal malignant melanoma

Fig. 4

a, b Patients with high tumor infiltrating lymphocytes (TIL) and tumor-associated macrophages (TAM) infiltrations show significantly better prognosis than those with low TIL and TAM infiltration (P = 0.007 and P = 0.035, respectively). c, d Patients with ARMM with high CD3+ T-cell infiltration in the tumor invasion front (P < 0.001), and in tumor center (P = 0.049), f high CD8+ T cell infiltration in the tumor center (P = 0.028) and g, h Foxp3+ T-cell infiltration in the invasion front (P = 0.033) and tumor center (P = 0.0088) show significantly better overall survival than those with low infiltration. Patients e CD8+ T-cell infiltration of the invasion front (P = 0.062) have no significant difference in terms of survival, but they show a trend toward a better overall survival compared to the low infiltration.

Back to article page