Fig. 5: Association of CD3+ T cells in invasion front and tumor stages according to various staging systems. | Modern Pathology

Fig. 5: Association of CD3+ T cells in invasion front and tumor stages according to various staging systems.

From: Distribution pattern of tumor infiltrating lymphocytes and tumor microenvironment composition as prognostic indicators in anorectal malignant melanoma

Fig. 5

The density of CD3+ T cell infiltration in invasion front was higher in lower stage groups than higher stage groups (mean ± SD) by a Ballantyne staging system (stage I vs stages II–III, 334.0 ± 184.9 vs 182.0 ± 90.7, P = 0.016), b Modified Ballantyne staging system (stage L vs stages R & D, 319.0 ± 176.4 vs 179.7 ± 93.6, P = 0.024), and d AJCC colorectal staging system, stages I–II vs stages III–IV, 371.0 ± 177.3 vs 177.3 ± 87.9, P = 0.002; Mann–Whitney U test). However, the density of CD3+ T cell infiltration in invasion front was tended to be different in lower stage groups than higher stage groups by c the AJCC cutaneous melanoma staging system (stages IIB–IIC vs stages III–IV, 340.0 ± 163.8 vs 205.8 ± 130.8, P = 0.089).

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