Fig. 1: Morphology of bone marrow and peripheral blood in MDS and AML with t(6;9). | Modern Pathology

Fig. 1: Morphology of bone marrow and peripheral blood in MDS and AML with t(6;9).

From: Myelodysplastic syndrome with t(6;9)(p22;q34.1)/DEK-NUP214 better classified as acute myeloid leukemia? A multicenter study of 107 cases

Fig. 1

A Bone marrow from a patient with MDS-EB2 with t(6;9) and mutations of NRAS and KRAS showed dysplastic neutrophils and megakaryocytes (insert), and increased basophils and blasts. Original magnification: ×1000. B Bone marrow from a patient with AML with t(6;9) and FLT3-ITD mutation showed trilineage dysplasia and increased myeloblasts. The patient had a history of MDS-EB2 with t(6;9). Insert: dysplastic megakaryocytes. Original magnification: ×1000. C Bone marrow from a patient with AML with t(6;9) and FLT3-ITD mutation showed numerous large monoblasts. The patient developed AML progression after HSCT for MDS-EB1 with t(6;9). Original magnification: ×1000. D Bone marrow from a patient with de novo AML with t(6;9) showed numerous medium-sized myeloblasts in a background of increased basophils and dysgranulopoiesis. Original magnification: ×1000.

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