Fig. 4: Illustration of the various fusion genes in hybrid schwannoma–perineurioma.
From: Hybrid schwannoma–perineurioma frequently harbors VGLL3 rearrangement
A Circos plot demonstrating the chromosomes involved in the various fusion events (image generated using FusionHub) [39]. Exon details for (B) each of the VGLL3 associated fusion partners and (C) unrelated fusion products (mRNA transcripts were extracted and plotted from the R package ggbio) [40]. Note: sky blue arrows and lines indicate the exons involved in the fusion and directions of transcription. D Representative images independently confirming rearrangement of (i) BRAF [three-color FISH break/fusion assay: arrows indicate representative tumor cells with deletion of the telomeric “green” BRAF signal, with corresponding fusion of the centromeric “yellow” BRAF signal to the intragenic “red” DST signal], and (ii) VGLL3 and (iii) CHD7 [break-apart assay: arrows indicate representative tumor cells with break-apart signals].
