Fig. 1: Analysis of the ADPR signal intensities in breast cancer. | Modern Pathology

Fig. 1: Analysis of the ADPR signal intensities in breast cancer.

From: Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers

Fig. 1

A IHC staining of a breast cancer TMA using the anti-ADPr antibody. cyADPR staining intensity scores: strong (red, 3), moderate (yellow, 2), and weak/negative (blue, 1). On the top, selected TMA cores (scale bar 100 µm, 10x), on the bottom, ROIs (scale bar 20 µm, 40x). Kaplan–Meier survival plot of (B) invasive ductal breast cancer (Mantel–Cox test, p value < 0.0001, N = 643) and (C) invasive lobular breast cancer (Mantel–Cox test, p value = 0.0017, N = 116) with patients stratified based on the cyADPR signal intensity scores. Contingency analysis to assess the association between cyADPR scores and the tumor stage (pT 1–4), the tumor grade (1–3), regional lymph node metastasis (pN 0–2), and the presence of distant metastasis (pM 0–1) in invasive ductal breast cancer (D, F, H, J) and in invasive lobular breast cancer (E, G, I, K).

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