Fig. 6: Representative histological images of conventional (keratin-negative, HMGA2-NCOR2 fusion-negative) giant cell tumors of soft tissue. | Modern Pathology

Fig. 6: Representative histological images of conventional (keratin-negative, HMGA2-NCOR2 fusion-negative) giant cell tumors of soft tissue.

From: Recurrent novel HMGA2-NCOR2 fusions characterize a subset of keratin-positive giant cell-rich soft tissue tumors

Fig. 6

A A subset of cases contained a peripheral shell or islands of mature metaplastic bone. B Higher magnification of A (note close similarity to the case depicted in Fig. 3A). C CD68 highlighted the osteoclastic cells, but was less expressed in the mononuclear cells in this case. D Consistent nuclear immunoreactivity with SATB2 is seen in the majority of these tumors, note lack of expression in the osteoclastic giant cells.

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