Fig. 6: Colonic NUTM1-rearranged sarcoma. | Modern Pathology

Fig. 6: Colonic NUTM1-rearranged sarcoma.

From: NUTM1-rearranged colorectal sarcoma: a clinicopathologically and genetically distinctive malignant neoplasm with a poor prognosis

Fig. 6

A All tumors expressed NUT protein in a nuclear pattern. B Keratin expression, here with the AE1/AE3 antibody cocktail, was present in all tumors but variable in extent. C Despite showing rhabdoid morphology and keratin expression, all tumors displayed retained expression of SMARCB1 (shown) and SMARCA4 (not shown). D A variety of other markers, including KIT and DOG1, was negative. Here a negative desmin immunostain highlights diffuse infiltration of the muscularis propria by tumor cells.

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