Table 3 Previously reported NUTM1-rearranged sarcomas.
Casea | Study (referencea) | Age/sex | Location | Histology | Keratins | NUT | Fusion type | Metastases | Outcome |
|---|---|---|---|---|---|---|---|---|---|
1 | Dickson et al. (2018) [20] | 61/M | Thigh | Round cell and epithelioid | Positive | Positive | BRD3-NUTM1 | Lymph node | DOD 3 months |
2 | 45/M | Arm | Epithelioid | Negative | Negative | BCORL1-NUTM1 | Lymph node, lung, soft tissue | DOD 48 months | |
3 | 39/F | Stomach | Rhabdoid | Positive | Negative | MXD1-NUTM1 | Widespread | AWD 108 months | |
4 | 3/M | Parietal cortex | Round cell | Negative | Positive | BRD4-NUTM1 | NA | DOD 3 months | |
5 | 71/F | Kidney | Round cell | Positive | Positive | BRD4-NUTM1 | Lung | DOD 2 months | |
6 | 36/F | Kidney | Epithelioid | Positive | Positive | BRD4-NUTM1 | Lung | DOD 6 months | |
7 | Diolati et al. [11] | 10/M | Thigh | Fibrosarcomatous with hyalinized collagen (amianthoid) | Negative | Positive | MGA-NUTM1 | None | ANED 11 years |
8 | 10/F | Dura | Fibrosarcomatous | Negative | Positive | MGA-NUTM1 | None | ANED 15 months | |
9 | Mangray et al. [12] | 13/F | Kidney | Round cell and rhabdoid | NA | Positive | CIC-NUTM1 | None | ANED 36 months |
10 | Schaefer et al. [13] | 60/M | Scalp | Round cell and rhabdoid with hyalinized collagen | Negative | Positive | CIC-NUTM1 | None | ANED 10 months |
11 | Stevens et al. [9] | 63/F | Lung | Spindle cell and myxoid | NA | Positive | MGA-NUTM1 | Liver | NA |
12 | 38/F | Lung | Round cell | Negative | NA | BRD4-NUTM1 | NA | NA | |
13 | 65/Fa | Colon | Rhabdoid with hyalinized collagen | Positive | Positive | MXD4-NUTM1 | Liver and lymph nodea | DOD 30 monthsa | |
14 | 48/M | Foot | Spindle cell and myxoid | Positive | Positive | X-NUTM1 | Lung | NA | |
15 | Le Loarer et al. [14] | 3/M | Temporal bone and brain | Round cell and spindled | NA | Positive | CIC-NUTM1 | NA | DOD 18 months |
16 | 5/M | Occipital bone and brain | Round cell, epithelioid and spindled | NA | Positive | CIC-NUTM1 | NA | DOD 14 months | |
17 | 7/F | Paravertebral | Round cell and epithelioid | NA | Positive | CIC-NUTM1 | NA | DOD 37 months | |
18 | 27/M | Lung | Round cell, epithelioid and spindled | NA | Positive | CIC-NUTM1 | NA | DOD 7 months | |
19 | 22/F | Lateral ventricle | Round cell and rhabdoid | NA | Positive | CIC-NUTM1 | NA | DOD 17 months | |
20 | 18/M | Thoracic epidural | Round cell and epithelioid | NA | Positive | CIC-NUTM1 | NA | ANED 40 months | |
21 | Mantilla et al. [15] | 61/M | Pleura | Round cell with hyalinized collagen (amianthoid) | Negative | Positive | MGA-NUTM1 | NA | NA |
22 | Chien et al. [16] | 21/F | Mandible | Epithelioid and rhabdoid | Negative | Positive | ZNF532-NUTM1 | None | ANED 3.6 years |
23 | Goto et al. [17] | 49/M | Lung | Fibrosarcomatous with hyalinized collagen (amianthoid) | Negative | Positive | MGA-NUTM1 | Lymph node | DOD 13 months |
24 | Underwood et al. [18] | 48/M | Foot | Epithelioid with hyalinized collagen | Negative | Positive | MGA-NUTM1 | Bone and lung | AWD 6 months |
