Fig. 2: Gene copy number alterations and somatic mutations identified in histologically distinct components of the mixed mesonephric and endometrioid carcinoma CX26.
Representative hematoxylin and eosin-stained sections of the histologically distinct components of CX26 (A), including mesonephric (top left), mesonephric exophytic (middle left), and endometrioid squamous (bottom left) components. Corresponding copy number plots of each component are shown (middle) with Log2-ratios on the y-axis and chromosome location on the x-axis. On the right, heatmaps depicting non-synonymous somatic mutations (left) and the cancer cell fractions of the mutations identified (right) in both histological components. B Maximum parsimony tree depicting the clonal evolution of the separate components of CX26. The branches are representative of each of the clones identified and selected somatic mutations and gene copy number alterations that define a given clone are illustrated along the branches. The length of the branches is representative of the number of somatic mutations and/or copy number alterations that distinguish a given clone from its ancestral clone.
